Endocrine Abstracts

Patients (pts) with hypoparathyroidism (HypoPT) are at risk to develop renal failure possibly caused by hypercalciuria and nephrocalcinosis. We retrospectively evaluated the data of 711 Patients with HypoPT in 3 endocrine centres in Germany.Methods: Records of 711 pts with HypoPT were reviewed. Patients were predominantly female (n=592, male: n=119; age 50.9±14.1 years, range 12 – 99 years). The following parameters were docum...

Introduction: Patients with hypoparathyroidism (hypoPT) suffer from a number of complaints and reduced quality of life (QoL) besides having serum values for disease-specific parameters in the target range. To be able to quantify symptoms in hypoPT patients we lately developed a disease-specific questionnaire, the Hypoparathyroidism patient questionnaire with 28 items (HPQ28). The aim of this study was to present normative values for the HPQ28.Methods: A ...

Introduction: Turner syndrome (TS) is characterized by the complete or partial loss of one X chromosome and associated with a wide range of clinical manifestations. The clinical appearance depends on the specific karyotype, which may include different mosaic forms. Main features of almost all the karyotypes are short stature and delayed or absent puberty. Adult women in particular are at high risk of developing cardiac complications, metabolic syndrome, increased liver enzyme ...

Introduction: Physiological glucocorticoids play an essential role in bone formation but can cause osteoporosis if present in excess. The key enzyme converting inactive cortisone into the active cortisol and vice versa is 11-beta-hydroxy-steroid-dehydrogenase (11β-HSD1). We have reported that genetic variations in the HSD11B1 gene correlate with increased cortisol levels in dexamethasone suppression and with changes in bone mineral density (BMD) suggesting indivi...

In hypoparathyroidism (HypoPT), patients suffer severely from reduced quality of life. The complexity of HypoPT demands a disease-specific control instrument to characterize symptom load. We employed a newly developed disease-specifichypoparathyroid patient questionnaire (the HPQ 40/28) to investigate and quantify HypoPT patients’ complaints and contributing factors. In this cross-sectional, two-center study, patients with postsurgical HypoPT (n = 49) were m...